TWO-STIMULI MANIPULATION OF A BIOLOGICAL MOTOR

Two-stimuli manipulation of a biological motor

Abstract F1-ATPase is an enzyme acting as a rotary nano-motor.During Toothpaste catalysis subunits of this enzyme complex rotate relative to other parts of the enzyme.Here we demonstrate that the combination of two input stimuli causes stop of motor rotation.Application of either individual stimulus did not significantly influence motor motion.Thes

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P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.We aimed to investigate the effect of the selective P2X3 antagonist A-317491 on visceral sensitivity under physiological conditions, during acute colitis and in the post-inflammatory phase of c

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